Angus Sinclair

Angus Sinclair

Company: IGM Biosciences

Job title: VP Immuno-Oncology

Seminars:

Multimeric IgM Antibodies Targeting DR5 are Potent and Rapid Inducers of Tumor Cell Apoptosis In Vitro and In Vivo 9:30 am

• IgM antibodies are naturally occurring multi-valent, high avidity antibodies and are potent cell surface receptor cross-linking agents • An engineered IgM antibody targeting TNFrSF family member Death Receptor 5 (DR5) IGM-8444, was developed and demonstrates potent apoptotic potential across multiple tumor types including breast in vitro; single agent efficacy in xenograft tumor models; synergistic…Read more

day: Day Two

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